Role of epigenetics in atherosclerosis and its consequent diseases
Keywords:
atherosclerosis, diseases resulting from atherosclerosis, epigenetics, methylation, Non-coding RNAsAbstract
Introduction: Atherosclerosis is a disease of multifactorial origin, which is aggravated as a result of an adverse environment and unhealthy lifestyles. This leads to epigenetic modifications in each individual, which are very dynamic, variable and do not constitute permanent changes in the expression of genes. This allows the establishment of prevention strategies aimed at the modification of these environmental factors and, therefore, at the modification of the expression of genes through epigenetic mechanisms.
Objective: To describe the relationship of epigenetics with atherosclerosis and its consequent diseases.
Methods: A documentary research study was conducted. The search and selection of documents was done on the Internet, through keywords. The search was organized into three sections in articles or researches: epigenetics, atherosclerosis and its consequent diseases. For the prioritization of the documents, the date of publication and relevance of the content were considered at the discretion of the author. 34 documents were selected.
Conclusions: Epigenetics offers explanations on how diet, environmental factors and lifestyle can influence the onset and progression of the disease, and how alterations can be transmitted to subsequent generations without modifications in DNA sequences. It also provides information about how these transformations influence the transmission and development of chronic diseases such as atherosclerosis and its consequent diseases.
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