Impact and effectiveness of Abdala vaccine in Matanzas province in the face of symptomatic disease and death from COVID-19
Keywords:
COVID-19, vacunas, efectividad, impacto, incidencia, mortalidadAbstract
Introduction: To obtain control of the COVID-19 epidemic in Cuba, the decision was made by the highest management of the government and the Ministry of Public Health to carry out a health intervention with Abdala vaccine in Matanzas province, due to its high incidence and mortality.
Objective: To estimate the impact and effectiveness of Abdala vaccine in the face of symptomatic disease of reported cases and death in hospitals in Matanzas province.
Methods: A retrospective cohort study was conducted, with a cohort of vaccinated people consisting of 252,557 people who met the three-dose schedule, and another of unvaccinated or who had not complied with the complete vaccination schedule of 325,462 people. Age and personal pathological history were explored. As a source of information, the registry of confirmed cases and deaths issued by the Ministry of Public Health and the automated vaccination base Andariego Higia were used. It was calculated the effectiveness (VE=1-RR) and by confidence intervals and analyzed epidemiological indicators with the Bayesian structural time series method. Results: The effectiveness against symptomatic disease and death was 75.5 % and 95.7 %, respectively. In the analysis of the causal impact, values of reduction of 90.0% of the reported incidence and 86.0% of mortality were evidenced with respect to the expected figures.
Conclusions: Abdala vaccine showed high effectiveness and impact in the prevention of symptomatic disease and death in real-world conditions.
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